Ranitidine
Description
Ranitidine is a histamin H2 receptor
antagonist. It inhibits basal and stimulated secretion of gastric
acid. Ranitidine is rapidly absorbed after oral administration.
Food or antacid does not interfere its absorption.
INDICATIONS
Ranitidine is indicated for the treatment
of duodenal ulcer, benign gastric ulcer, postoperative ulcer,
reflux esophagitis, zollinger-ellison syndrome and in other conditions
where reduction of gastric acidity is beneficial.
CLINICAL PHARMACOLOGY
Renitidine is potent histamin HL
receptor antagonist and inhibits gastric acid secretion elicited
by histamine. Renitidine also inhibits acid secretion elicited
by gastrin and, to a lesser extent, by muscarinic agonists. Renitidine
inhibits basal and nocturnal acid secretion and that simulated
by food, fundic distention, and various drugs. It reduces both
the volume and acid concentration of gastric juice. the out put
of pepsin and secretion of intrinsic factor are also reduced.
Ranitidine is readily absorbed from the gastrointestinal tract
with peak concentration in plasma occurring about 2 to 3 hours
after oral administration. The bioavailability of ranitidine is
about 50% due to first-pass metabolism. The elimination half-life
from plasma is around 2 to 3 hours and ranitidine is weakly bound
to plasma protein (about 15%). A small proportion of ranitidine
is metabolized in the liver and is excreted unchanged in the urine.
ranitidine crosses the placental barrier and is excreted into
breast milk.
Dosage And Administration
Duodenal and Gastric ulcer : The
usual dosage is 150 mg twice daily taken in the morning and evening
or 300 mg as a single dose at night for 4 to 8 weeks.
Reflux esophagitis : 150 mg twice daily or 300mg at bed time for
up to 8 weeks.
Zollinger-Ellison syndrome : 150 mg 3 times daily, if necessary
increased up to 6g daily in divided doses. Dosages should be continued
as long as clinically indicated.
Episodic Dyspepsia : 150 mg twice daily or 300 mg at bed time
for up to 6 weeks.
Maintenance therapy : 150 mg at night for preventing ulcer recurrences.
Side Effects
Ranitidine is well toleratd and side effects are usually uncommon.
Altered bowel habit, dizziness, rash, tiredness, reversible confessional
states, headache, ecreased blood counts, muscle or joint pain
have rarely been reported.
Precautions
Ranitidine should be given in reduced dosage to patients with
impaired renal and hepatic function.
Pregnancy
Ranitidine crosses the placenta. But there is no evidence of impaired
fertility or harm to the fetus due to Ranitidine. Like other drugs,
Ranitidine should only be used during pregnancy if considered
essential.
Nursing Mothers
Ranitidine is excreted in human breast milk. Caution should be
exercised when the drug is administered to a nursing mother.
Pharmaceutical Precautionss
Store in a cool and dry place. Protect from light.
|
Name of
Product
|
Pharmaceuticals
|
| Acin |
Bio-Pharma |
| Denitine |
Doctor's
Chemical Works |
| Editin-R |
Edruk |
| Gepin |
General Pharma |
| Hi-Tac |
Hudson |
| Inseac |
Inseac |
| Lumeran |
Ariastopharma |
| Neoceptin-R |
Beximco |
| Neotac |
Square pharma |
| Neotin |
Nipa |
| Norma-H |
Renata |
| Peptil-H |
Eskayef |
| Ranitidin |
Acme |
| Rani-150 |
Alco Pharma |
| Ranison |
Jayson Pharma
|
| Ranitid |
Opsonin Chemical |
| Ranitidin-R |
Remedy Pharma |
| Ranix |
Chemist Lab |
| Reetac-R |
Navana |
| Renicon |
Medicon |
| Ulcar |
Drug International
|
| Ultradin-150 |
Globe |
| Xantid/Xantid-HS |
ACI |
| Zactin |
Aventis Pharma |
| Zantac |
GlaxoSmithKline |
| Zodin |
Somatec |
| Zorep |
Amico |
